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Institut für Medizinische Molekulargenetik

Forschung - Research

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Mission

We aim to understand the molecular basis and pathophysiology of human diseases as a prerequisite to develop novel therapeutic interventions.

Goals

- Identification of new genes and mutations in human diseases
- Characterization of gene function in normal physiology and disease
- Functional analyses of mutations at the molecular level
- Development of therapeutic treatment approaches for genetic diseases

Acknowledgements

We are very grateful to all patients and their families as well as various patient organizations for their tremendous support of our research activities.

Funding

EMDO Stiftung
Hartmann Müller Stiftung
Novartis Stiftung
Olga Mayenfisch Stiftung
Retina Suisse
Schweizerische Herzstiftung
Schweizerischer Fonds zur Verhütung und Bekämpfung von Blindheit
Schweizerischer Nationalfonds (SNF)
Universität Zürich (Forschungskredit)
Dr. Werner Jackstädt Stiftung
Velux Stiftung

Weiterführende Informationen

organoid_axons

Human Retinal Organoid

This retinal organoid was derived from human induced pluripotent stem cells (hiPSCs) and grown in Matrigel. Fine extensions are seen emerging from the organoid, which are presumptive axons of developing retinal ganglion cells.

Flatmounts_3

Retinal Blood Vessel Staining

Flatmount preparations of wildtype (wt, left image) and Norrin knockout (ko, right image) mouse retinas at postnatal day 8 stained with Alexa Fluor 488 - labelled isolectin B4.

Default Caption

Section of a cerebral blood vessel stained with a Collagen IV antibody

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